Article
ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists - 1 Sept 2015
Lisi Simonetta, Madsen Peder, Botta Roberta, Petersen Claus Munck, Nykjær Anders, Latrofa Francesco, Vitti Paolo, Marinò Michele
Abstract excerpt
OBJECTIVE: The Vps10p family member sortilin is expressed in thyroid epithelial cells where it contributes to recycling of the thyroid hormone precursor thyroglobulin (Tg), a process that is thought to render hormone release more effective. Here we investigated the functional impact of sortilin in the thyroid gland using sortilin-deficient mice. METHODS: We measured free T4, thyroid-stimulating hormone (TSH) and...
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