Article
ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 1998
Günther W, Lüchow A, Cluzeaud F, Vandewalle A, Jentsch T J
Abstract excerpt
Loss-of-function mutations of the ClC-5 chloride channel lead to Dent's disease, a syndrome characterized by low molecular weight proteinuria, hypercalciuria, and kidney stones. We show that ClC-5 is expressed in renal proximal tubule cells, which normally endocytose proteins passing the glomerul...
Topics
- Chloride Channels
- Endocytosis
- Humans
- Kidney
- Mutation
- Nephrocalcinosis
- Proton Pumps
- Syndrome
- Transfection