Article
Examination of megalin in renal tubular epithelium from patients with Dent disease.
Pediatric nephrology (Berlin, Germany) - 1 Jun 2004
Santo Yoko, Hirai Haruhiko, Shima Masaaki, Yamagata Masayo, Michigami Toshimi, Nakajima Shigeo, Ozono Keiichi
Abstract excerpt
Dent disease is characteristic for the urinary loss of low-molecular-weight proteins and calcium, leading to renal calcification and, in some patients, chronic renal failure. This disorder is caused by loss-of-function mutations in the renal chloride channel gene, CLCN5. The animal model of this disease has demonstrated the possible role of disturbed megalin expression, which is a member of the low-density...
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