The association between promoter polymorphism of the interleukin-10 gene and Alzheimer's disease.

doi:10.1016/j.neurobiolaging.2004.08.010

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Article

The association between promoter polymorphism of the interleukin-10 gene and Alzheimer's disease.

Neurobiology of aging - 1 Jul 2005

Ma Suk Ling, Tang Nelson Leung Sang, Lam Linda Chiu Wa, Chiu Helen Fung Kum

Abstract excerpt

The importance of the role of inflammation has been suggested in the pathogenesis of Alzheimer's disease (AD). Interleukin-10 (IL-10) is an anti-inflammatory cytokine that may modulate the progression of the disease through the inhibition of the action of pro-inflammatory cytokines. In this study, three polymorphisms in the regulatory region of the IL-10 gene (-1082, -819 and -592) in 95 Chinese AD patients and...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Blotting, Northern
C-Reactive Protein
Case-Control Studies
Chi-Square Distribution
Confidence Intervals
Enzyme-Linked Immunosorbent Assay
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Frequency

Genetic Predisposition to Disease

Genotype

Humans

Interleukin-10

Linkage Disequilibrium

Male

Source

Open in PubMed

Identifiers

PMID: 15748779
DOI: 10.1016/j.neurobiolaging.2004.08.010

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