Article
Partial inhibition of PP1 alters bidirectional synaptic plasticity in the hippocampus.
The European journal of neuroscience - 1 Jul 2006
Jouvenceau Anne, Hédou Gael, Potier Brigitte, Kollen Mélanie, Dutar Patrick, Mansuy Isabelle M
Abstract excerpt
Synaptic plasticity is an important cellular mechanism that underlies memory formation. In brain areas involved in memory such as the hippocampus, long-term synaptic plasticity is bidirectional. Major forms of bidirectional plasticity encompass long-term potentiation (LTP), LTP reversal (depotentiation) and long-term depression (LTD). Protein kinases and protein phosphatases are important players in the induction...
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