Article

BACE1 in PV interneuron tunes hippocampal CA1 local circuits and resets priming of fear memory extinction

2022-10-06

Abstract excerpt

<title>Abstract</title> <p>BACE1 is the rate-limiting enzyme for β-amyloid (Aβ) production and therefore is considered a prime drug target for treating Alzheimer’s disease (AD). Nevertheless, the BACE1 inhibitors failed in clinical trials, even exhibiting cognitive worsening, implying that BACE1 may function in regulating cognition-relevant neural circuits. Here, we found that parvalbumin-positive inhibitory inte...

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Literature Corpus work: 8caf4dd0-a92b-5307-b979-650446df7816
DOI: 10.21203/rs.3.rs-2017936/v1

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