Article
Bidirectional regulation of hippocampal long-term synaptic plasticity and its influence on opposing forms of memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 Mar 2010
Malleret Gaël, Alarcon Juan M, Martel Guillaume, Takizawa Shuichi, Vronskaya Svetlana, Yin Deqi, Chen Irene Z, Kandel Eric R, Shumyatsky Gleb P
Abstract excerpt
Reference memory characterizes the long-term storage of information acquired through numerous trials. In contrast, working memory represents the short-term acquisition of trial-unique information. A number of studies in the rodent hippocampus have focused on the contribution of long-term synaptic potentiation (LTP) to long-term reference memory. In contrast, little is known about the synaptic plasticity...
Topics
- Animals
- Cyclic AMP-Dependent Protein Kinases
- Hippocampus
- Male
- Memory
- Mice
- Mice, Inbred CBA
- Mice, Transgenic
- Mutation
- Neural Pathways
- Neuronal Plasticity
- Time Factors