Article
Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.
Nature - 3 Dec 1998
Migaud M, Charlesworth P, Dempster M, Webster L C, Watabe A M, Makhinson M, He Y, Ramsay M F, Morris R G, Morrison J H, O'Dell T J, Grant S G
Abstract excerpt
Specific patterns of neuronal firing induce changes in synaptic strength that may contribute to learning and memory. If the postsynaptic NMDA (N-methyl-D-aspartate) receptors are blocked, long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission and the learning of spat...
Topics
- Animals
- Disks Large Homolog 4 Protein
- Electrophysiology
- Gene Targeting
- Guanylate Kinases
- Hippocampus
- Intracellular Signaling Peptides and Proteins
- Learning
- Learning Disabilities
- Long-Term Potentiation
- Maze Learning