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Article

Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.

Thrombosis research - 1 Jan 2007

Kimura Rina, Miyashita Kotaro, Kokubo Yoshihiro, Akaiwa Yasuhisa, Otsubo Ryoichi, Nagatsuka Kazuyuki, Otsuki Toshiho, Okayama Akira, Minematsu Kazuo, Naritomi Hiroaki, Honda Shigenori, Tomoike Hitonobu, Miyata Toshiyuki

Abstract excerpt

The dose required for the anticoagulant effect of warfarin exhibits large inter-individual variations. This study sought to determine the contribution of four genes, vitamin K epoxide reductase (VKORC1), gamma-glutamyl carboxylase (GGCX), calumenin (CALU), and cytochrome P450 2C9 (CYP2C9) to the...

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Source

Identifiers

PMID: 17049586
DOI: 10.1016/j.thromres.2006.09.007

Genes

GGCX
VKORC1
CALU

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17049586-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.PMID 17049586Read ↗

VKORC1 gene variations are the major contributors of variation in warfarin dose in Japanese patients.Semantic proximity Read ↗

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High-resolution SNP and haplotype maps of the human gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population.Semantic proximity Read ↗

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Association of genetic polymorphisms with warfarin dose requirements in Chinese patients.Semantic proximity Read ↗

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