Article
Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice.
Regulatory peptides - 11 Sept 2006
Faber Franziska, Gembardt Florian, Sun Xiaoou, Mizutani Shigehiko, Siems Wolf-Eberhard, Walther Thomas
Abstract excerpt
Elevated central concentrations of the vasopressor octapeptide angiotensin (Ang) II increase the water intake in mammals. Recently, we showed that central AngII is also crucial in alcohol-consuming behavior. Since the heptapeptide AngIII, an AngII metabolite, is discussed to mediate AngII-related effects, we investigated water and alcohol consumption in mice, genetically deficient in aminopeptidase A (APA), a...
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