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Article

Local production of angiotensin II in the subfornical organ causes elevated drinking

2 Apr 2007

Abstract excerpt

The mechanism controlling cell-specific Ang II production in the brain remains unclear despite evidence supporting neuron-specific renin and glial- and neuronal-specific angiotensinogen (AGT) expression. We generated double-transgenic mice expressing human renin (hREN) from a neuron-specific promoter and human AGT (hAGT) from its own promoter (SRA mice) to emulate this expression. SRA mice exhibited an increase...

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PMID: 17404622
DOI: 10.1172/jci31242

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