Article
Analysis of the vasopressin system and water regulation in genetically polydipsic mice.
American journal of physiology. Endocrinology and metabolism - 1 Feb 2000
Yambe Y, Watanabe-Tomita Y, Kakiya S, Yokoi H, Nagasaki H, Arima H, Murase T, Yuasa H, Kondo K, Yamashita H, Oiso Y
Abstract excerpt
Polydipsic mice, STR/N, which show extreme polydipsia and polyuria, were discovered in 1958. In the STR/N, urine outputs are much higher than in control mice. The possibility of an abnormal regulation of the arginine vasopressin (AVP) system, or an abnormality in the renal susceptibility to AVP, should be considered. In this study we investigated the AVP system and water regulation in STR/N. We sequenced the AVP...
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