Article
Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Apr 2001
Morris M, Means S, Oliverio M I, Coffman T M
Abstract excerpt
The objective was to determine the central nervous system (CNS) responses to dehydration (c-Fos and vasopressin mRNA) in mice lacking the ANG AT(1a) receptor [ANG AT(1a) knockout (KO)]. Control and AT(1a) KO mice were dehydrated for 24 or 48 h. Baseline plasma vasopressin (VP) was not different between the groups; however, the response to dehydration was attenuated in AT(1a) KO (24 +/- 11 vs. 10.6 +/- 2.7 pg/ml)....
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