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Article

Neutral endopeptidase and alcohol consumption, experiments in neutral endopeptidase-deficient mice.

European journal of pharmacology - 2 Jun 2000

Siems W, Maul B, Krause W, Gerard C, Hauser K F, Hersh L B, Fischer H S, Zernig G, Saria A

Abstract excerpt

Alcohol consumption was investigated in mice which were rendered deficient in the peptide-degrading enzyme neutral endopeptidase (EC 3.4.24.11) (NEP-/-) by gene targeting and compared to alcohol consumption in corresponding wild type mice (NEP+/+). Mice were offered a free choice to drink tap water or 10% alcohol. The NEP-/- mice consumed significantly more alcohol ( approximately 42%) than the NEP+/+ mice,...

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PMID: 10844131
DOI: 10.1016/s0014-2999(00)00222-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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