Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zebrafish genomic instability mutants and cancer susceptibility.

Genetics - 1 Oct 2006

Moore Jessica L, Rush Lindsay M, Breneman Carol, Mohideen Manzoor-Ali P K, Cheng Keith C

Abstract excerpt

Somatic loss of tumor suppressor gene function comprising the second hit of Knudson's two-hit hypothesis is important in human cancer. A genetic screen was performed in zebrafish (Danio rerio) to find mutations that cause genomic instability (gin), as scored by Streisinger's mosaic-eye assay that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genomic Instability
Share to Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Phenotype

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 16888336
DOI: 10.1534/genetics.106.059386
PMCID: PMC1602069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16888336-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zebrafish genomic instability mutants and cancer susceptibility.PMID 16888336Read ↗

Mosaic eyes, genomic instability mutants, and cancer susceptibility.Semantic proximity Read ↗

Rapid tumor induction in zebrafish by TALEN-mediated somatic inactivation of the retinoblastoma1 tumor suppressor rb1.Semantic proximity Read ↗

Zebrafish as a cancer model.Semantic proximity Read ↗

From Zebrafish to human: modular medical models.Semantic proximity Read ↗

A genetic screen for mutations affecting embryogenesis in zebrafish.Semantic proximity Read ↗

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs.Semantic proximity Read ↗

Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma.Semantic proximity Read ↗

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.Semantic proximity Read ↗

A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly.Semantic proximity Read ↗

Large-scale forward genetic screening of zebrafish affecting thyroid development.Semantic proximity Read ↗

Making waves in cancer research: new models in the zebrafish.Semantic proximity Read ↗

Tumor Suppressors in Zebrafish: From TP53 to PTEN and Beyond.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.