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Article

Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma.

Molecular cancer research : MCR - 1 Jun 2009

Amsterdam Adam, Lai Kevin, Komisarczuk Anna Z, Becker Thomas S, Bronson Roderick T, Hopkins Nancy, Lees Jacqueline A

Abstract excerpt

We screened an existing collection of zebrafish insertional mutants for cancer susceptibility by histologic examination of heterozygotes at 2 years of age. As most mutants had no altered cancer predisposition, this provided the first comprehensive description of spontaneous tumor spectrum and frequency in adult zebrafish. Moreover, the screen identified four lines, each carrying a different dominant mutant allele...

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Identifiers

PMID: 19531571
DOI: 10.1158/1541-7786.MCR-08-0555
PMCID: PMC2744123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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