Article
Large-scale forward genetic screening of zebrafish affecting thyroid development.
Biochemical and biophysical research communications - 29 Jan 2023
Wan Jia-Ping, Wang Zheng, Zhang Cao-Xu, Fang Ya, Yang Liu, Yan Chen-Yan, Wu Feng-Yao, Zhao Shuang-Xia, Song Huai-Dong, Dong Mei
Abstract excerpt
The thyroid follicular cells originate from the foregut endoderm and elucidating which genes and signaling pathways regulate their development is crucial for understanding developmental disorders as well as diseases in adulthood. We exploited unique advantages of the zebrafish model to carry an ENU-based forward mutagenesis screen aiming at identifying genes involved in the development and function of the thyroid...
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