Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation.

The Journal of clinical investigation - 1 Aug 2006

Wang Honglin, Peters Thorsten, Kess Daniel, Sindrilaru Anca, Oreshkova Tsvetelina, Van Rooijen Nico, Stratis Athanasios, Renkl Andreas C, Sunderkötter Cord, Wlaschek Meinhard, Haase Ingo, Scharffetter-Kochanek Karin

Abstract excerpt

The CD18 hypomorphic (CD18hypo) PL/J mouse model clinically resembling human psoriasis is characterized by reduced expression of the common chain of beta2 integrins (CD11/CD18) to only 2-16% of WT levels. Previously we found that this chronic psoriasiform skin inflammation also depends on the presence of CD4+ T cells. Herein we investigated the role of macrophages in this CD18hypo mouse model. Activated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD11 Antigens
Share to CD18 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CCL2

Share to Inflammation

Share to Macrophage Activation

Share to Mice, Inbred Strains

Share to Psoriasis

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 16886059
DOI: 10.1172/JCI27180
PMCID: PMC1523400

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation.PMID 16886059Read ↗

CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis.Semantic proximity Read ↗

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation.Semantic proximity Read ↗

Psoriasiform dermatitis susceptibility in Itgb2(tm1Bay) PL/J mice requires low-level CD18 expression and at least two additional loci for progression to severe disease.Semantic proximity Read ↗

Pristane-induced granulocyte recruitment promotes phenotypic conversion of macrophages and protects against diffuse pulmonary hemorrhage in Mac-1 deficiency.Semantic proximity Read ↗

A 9-centimorgan interval of chromosome 10 controls the T cell-dependent psoriasiform skin disease and arthritis in a murine psoriasis model.Semantic proximity Read ↗

Misbehaving macrophages in the pathogenesis of psoriasisSemantic proximity Read ↗

Macrophage-mediated psoriasis can be suppressed by regulatory T lymphocytes.Semantic proximity Read ↗

Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice.Semantic proximity Read ↗

Regulation of inflammation and fibrosis by macrophages in lymphedema.Semantic proximity Read ↗

Chemokines and inflammatory skin diseases.Semantic proximity Read ↗

Extracellular adherence protein of Staphylococcus aureus suppresses disease by inhibiting T-cell recruitment in a mouse model of psoriasis.Semantic proximity Read ↗

Depletion of antigen-presenting cells by clodronate liposomes reverses the psoriatic skin phenotype in KC-Tie2 mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.