Article
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation.
The Journal of clinical investigation - 1 Aug 2006
Stratis Athanasios, Pasparakis Manolis, Rupec Rudolf A, Markur Doreen, Hartmann Karin, Scharffetter-Kochanek Karin, Peters Thorsten, van Rooijen Nico, Krieg Thomas, Haase Ingo
Abstract excerpt
Psoriasis is a common skin disease, the pathogenesis of which has not yet been resolved. In mice, epidermis-specific deletion of inhibitor of NF-kappaB (IkappaB) kinase 2 (IKK2) results in a skin phenotype that mimics human psoriasis in several aspects. Like psoriasis, this skin disease shows pronounced improvement when mice are treated with a TNF-neutralizing agent. We have found previously that this phenotype...
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