Article
CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2003
Kess Daniel, Peters Thorsten, Zamek Jan, Wickenhauser Claudia, Tawadros Samir, Loser Karin, Varga Georg, Grabbe Stephan, Nischt Roswitha, Sunderkötter Cord, Müller Werner, Krieg Thomas, Scharffetter-Kochanek Karin
Abstract excerpt
In a CD18 hypomorphic polygenic PL/J mouse model, the severe reduction of CD18 (beta(2) integrin) to 2-16% of wild-type levels leads to the development of a psoriasiform skin disease. In this study, we analyzed the influence of reduced CD18 gene expression on T cell function, and its contribution to the pathogenesis of this disease. Both CD4(+) and CD8(+) T cells were significantly increased in the skin of...
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