Article
Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice.
The American journal of pathology - 1 Feb 2011
Singh Tej Pratap, Huettner Barbara, Koefeler Harald, Mayer Gerlinde, Bambach Isabella, Wallbrecht Katrin, Schön Michael P, Wolf Peter
Abstract excerpt
Platelet-activating factor (PAF), a potent biolipid mediator, is involved in a variety of cellular transduction pathways and plays a prominent role in inducing inflammation in different organs. We used K5.hTGF-β1 transgenic mice, which exhibit an inflammatory skin disorder and molecular and cytokine abnormalities with strong similarities to human psoriasis, to study the pathogenic role of PAF. We found that...
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