Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macrophage-mediated psoriasis can be suppressed by regulatory T lymphocytes.

The Journal of pathology - 1 Nov 2016

Leite Dantas Rafael, Masemann Dörthe, Schied Tanja, Bergmeier Vera, Vogl Thomas, Loser Karin, Brachvogel Bent, Varga Georg, Ludwig Stephan, Wixler Viktor

Abstract excerpt

We recently described an inducible human TNF transgenic mouse line (ihTNFtg) that develops psoriasis-like arthritis after doxycycline stimulation and analysed the pathogenesis of arthritis in detail. Here, we show that the skin phenotype of these mice is characterized by hyperproliferation and aberrant activation of keratinocytes, induction of pro-inflammatory cytokines, and infiltration with Th1 and Treg...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Cellular Microenvironment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Keratinocytes

Share to Macrophages

Share to Psoriasis

Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 27555499
DOI: 10.1002/path.4786

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macrophage-mediated psoriasis can be suppressed by regulatory T lymphocytes.PMID 27555499Read ↗

Misbehaving macrophages in the pathogenesis of psoriasisSemantic proximity Read ↗

Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation.Semantic proximity Read ↗

New findings of macrophages in initiating and sustaining psoriasisSemantic proximity Read ↗

Mouse models of psoriasis and their relevanceSemantic proximity Read ↗

The role of regulatory T cells and anti-inflammatory cytokines in psoriasis.Semantic proximity Read ↗

T Helper Cell Subsets in Clinical Manifestations of Psoriasis.Semantic proximity Read ↗

Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha.Semantic proximity Read ↗

The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part I: Treg properties and functionsSemantic proximity Read ↗

Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder.Semantic proximity Read ↗

CD8(+) T cells mediate RAS-induced psoriasis-like skin inflammation through IFN-γ.Semantic proximity Read ↗

Peptidoglycan Recognition Protein Pglyrp2 Protects Mice from Psoriasis-like Skin Inflammation by Promoting Regulatory T Cells and Limiting Th17 ResponsesSemantic proximity Read ↗

Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.