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Article

Regulation of inflammation and fibrosis by macrophages in lymphedema.

American journal of physiology. Heart and circulatory physiology - 1 May 2015

Ghanta Swapna, Cuzzone Daniel A, Torrisi Jeremy S, Albano Nicholas J, Joseph Walter J, Savetsky Ira L, Gardenier Jason C, Chang David, Zampell Jamie C, Mehrara Babak J

Abstract excerpt

Lymphedema, a common complication of cancer treatment, is characterized by inflammation, fibrosis, and adipose deposition. We have previously shown that macrophage infiltration is increased in mouse models of lymphedema. Because macrophages are regulators of lymphangiogenesis and fibrosis, this study aimed to determine the role of these cells in lymphedema using depletion experiments. Matched biopsy specimens of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25724493
DOI: 10.1152/ajpheart.00598.2014
PMCID: PMC4551121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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