Article
Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity.
The Journal of biological chemistry - 18 Jun 2004
Padilla Sergio, Jonassen Tanya, Jiménez-Hidalgo María A, Fernández-Ayala Daniel José M, López-Lluch Guillermo, Marbois Beth, Navas Plácido, Clarke Catherine F, Santos-Ocaña Carlos
Abstract excerpt
Caenorhabditis elegans clk-1 mutants cannot produce coenzyme Q(9) and instead accumulate demethoxy-Q(9) (DMQ(9)). DMQ(9) has been proposed to be responsible for the extended lifespan of clk-1 mutants, theoretically through its enhanced antioxidant properties and its decreased function in respiratory chain electron transport. In the present study, we assess the functional roles of DMQ(6) in the yeast Saccharomyces...
Topics
- Alleles
- Antioxidants
- Benzoquinones
- Binding Sites
- Blotting, Western
- Chromatography, High Pressure Liquid
- Electron Transport
- Flow Cytometry
- Glycerol
- Hydrogen Peroxide
- Mass Spectrometry
- Mitochondria