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Article

Molecular mechanism of maternal rescue in the clk-1 mutants of Caenorhabditis elegans.

The Journal of biological chemistry - 5 Dec 2003

Burgess Jason, Hihi Abdelmadjid K, Benard Claire Y, Branicky Robyn, Hekimi Siegfried

Abstract excerpt

The clk-1 mutants of Caenorhabditis elegans display an average slowing down of physiological rates, including those of development, various behaviors, and aging. clk-1 encodes a hydroxylase involved in the biosynthesis of the redox-active lipid ubiquinone (co-enzyme Q), and in clk-1 mutants, ubiq...

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PMID: 14517217
DOI: 10.1074/jbc.M308507200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14517217-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Molecular mechanism of maternal rescue in the clk-1 mutants of Caenorhabditis elegans.PMID 14517217Read ↗

Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans.Semantic proximity Read ↗

C. elegans knockouts in ubiquinone biosynthesis genes result in different phenotypes during larval development.Semantic proximity Read ↗

Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging.Semantic proximity Read ↗

Sensitivity of Caenorhabditis elegans clk-1 mutants to ubiquinone side-chain length reveals multiple ubiquinone-dependent processes.Semantic proximity Read ↗

CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1.Semantic proximity Read ↗

Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/- mice.Semantic proximity Read ↗

Elevated mitochondrial DNA copy number found in ubiquinone-deficient clk-1 mutants is not rescued by ubiquinone precursor 2-4-dihydroxybenzoate.Semantic proximity Read ↗

A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Quinones in long-lived clk-1 mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage.Semantic proximity Read ↗

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