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Article

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.

Cancer cell - 1 Aug 2006

Rai Rekha, Dai Hui, Multani Asha S, Li Kaiyi, Chin Koei, Gray Joe, Lahad John P, Liang Jiyong, Mills Gordon B, Meric-Bernstam Funda, Lin Shiaw-Yih

Abstract excerpt

BRIT1, initially identified as an hTERT repressor, has additional functions at DNA damage checkpoints. Here, we demonstrate that BRIT1 formed nuclear foci minutes after irradiation. The foci of BRIT1 colocalized with 53BP1, MDC1, NBS1, ATM, RPA, and ATR. BRIT1 was required for activation of these elements, indicating that BRIT1 is a proximal factor in the DNA damage response pathway. Depletion of BRIT1 increased...

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Source

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Identifiers

PMID: 16872911
DOI: 10.1016/j.ccr.2006.07.002
PMCID: PMC1557410

Genes

ATM
ATR
MDC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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