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Differential regulation of centrosome integrity by DNA damage response proteins

15 Jul 2008

Abstract excerpt

MDC1 and BRIT1 have been shown to function as key regulators in response to DNA damage. However, their roles in centrosomal regulation haven't been elucidated. In this study, we demonstrated the novel functions of these two molecules in regulating centrosome duplication and mitosis. We found that MDC1 and BRIT1 were integral components of the centrosome that colocalize with gamma-tubulin. Depletion of either...

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PMID: 18635967
DOI: 10.4161/cc.7.14.6303

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