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Article

DNA Damage Response Pathways in Tumor Suppression and Cancer Treatment

26 Nov 2008

Abstract excerpt

Mammalian cells are frequently at risk of DNA damage from multiple sources. Accordingly, cells have evolved the DNA damage response (DDR) pathways to monitor the integrity of their genome. Conceptually, DDR pathways contain three major components (some with overlapping functions): sensors, signal transducers, and effectors. At the level of sensors, ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related)...

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PMID: 19034564
DOI: 10.1007/s00268-008-9840-1

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