Article
Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model.
The European journal of neuroscience - 1 Jul 2007
Butovsky Oleg, Kunis Gilad, Koronyo-Hamaoui Maya, Schwartz Michal
Abstract excerpt
We have recently shown that the ability of microglia to effectively fight off aggregated beta-amyloid plaque formation and cognitive loss in transgenic mouse models of Alzheimer's disease (Tg-AD), is augmented in response to T-cell-based immunization, using glatiramer acetate (GA). The immunization increases incidence of local CD11c+ dendritic-like cells. It is unclear, however, whether these dendritic cells are...
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