Article

3D models of Alzheimer’s disease patient microglia recapitulate disease phenotype and show differential drug responses compared to 2D

2021-07-29

Abstract excerpt

<title>Abstract</title> <p> Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clinical benefit. Neuroinflammation is a major contributor to neurodegeneration and hence, microglia, the brain’s resident immune cells, are an attractive target for potentially more...

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Literature Corpus work: d84660a0-da44-5dc4-9780-ed60c8982ef6
DOI: 10.21203/rs.3.rs-571254/v2

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