Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anti-α4β1 Integrin Antibodies Attenuated Brain Inflammatory Changes in a Mouse Model of Alzheimer's Disease.

Current Alzheimer research - 1 Jan 2018

Manocha Gunjan, Ghatak Atreyi, Puig Kendra, Combs Colin

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is associated with age-associated central nervous system degeneration and dementia. This decline in the function correlates with deposition of Aβ peptide containing plaques and associated reactive gliosis. The inflammatory phenotype of microglia, in particular, is often considered detrimental to cognitive function in AD. In addition to the changes in the CNS, altered immune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies

Share to Cytokines

Share to Encephalitis

Share to Gliosis

Share to Presenilin-1

Source

Open in PubMed Open full text

Identifiers

PMID: 30068274
DOI: 10.2174/1567205015666180801111033
PMCID: PMC6302348

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anti-α4β1 Integrin Antibodies Attenuated Brain Inflammatory Changes in a Mouse Model of Alzheimer's Disease.PMID 30068274Read ↗

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.Semantic proximity Read ↗

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic miceSemantic proximity Read ↗

Intravenous anti-Aβ immunotherapy acutely increases cerebral amyloid angiopathy and vascular damages in APOE4 miceSemantic proximity Read ↗

Immunomodulation of AβPP processing alleviates amyloid-β-related pathology in Alzheimer's disease transgenic mice.Semantic proximity Read ↗

Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1.Semantic proximity Read ↗

Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.Semantic proximity Read ↗

Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9.Semantic proximity Read ↗

The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.Semantic proximity Read ↗

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice.Semantic proximity Read ↗

C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology.Semantic proximity Read ↗

Therapeutic B-cell depletion reverses progression of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.