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Article

Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9.

Journal of neurochemistry - 1 Dec 2009

Koronyo-Hamaoui Maya, Ko Minhee K, Koronyo Yosef, Azoulay David, Seksenyan Akop, Kunis Gilad, Pham Michael, Bakhsheshian Joshua, Rogeri Patricia, Black Keith L, Farkas Daniel L, Schwartz Michal

Abstract excerpt

Immunization with an altered myelin-derived peptide (MOG45D) improves recovery from acute CNS insults, partially via recruitment of monocyte-derived macrophages that locally display a regulatory activity. Here, we investigated the local alterations in the cellular and molecular immunological milieu associated with attenuation of Alzheimer's disease-like pathology following immunotherapy. We found that...

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PMID: 19780903
DOI: 10.1111/j.1471-4159.2009.06402.x

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