Article

3D models of Alzheimer’s disease patient microglia recapitulate disease phenotype and show differential drug responses compared to 2D

2021-03-17

Abstract excerpt

Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clinical benefit. Neuroinflammation is a major contributor to neurodegeneration and hence, microglia, the brain’s resident immune cells, are an attractive target for potentially more effective therapeutic strateg...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a15d8c20-08ea-5f9c-9730-f9d1a8eea31b
DOI: 10.1101/2021.03.17.435758

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

3D models of Alzheimer’s disease patient microglia recapitulate disease phenotype and show differential drug responses compared to 2DDOI 10.1101/2021.03.17.435758Read

3D models of Alzheimer’s disease patient microglia recapitulate disease phenotype and show differential drug responses compared to 2DSemantic proximity Read

Systematically understanding the key roles of microglia in AD developmentSemantic proximity Read

Pathogenesis, therapeutic strategies and biomarker development based on “omics” analysis related to microglia in Alzheimer’s diseaseSemantic proximity Read

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentialsSemantic proximity Read

Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic interventionSemantic proximity Read

Microglia in Alzheimer’s DiseaseSemantic proximity Read

Microglia-Associated Neuroinflammation in Alzheimer’s DiseaseSemantic proximity Read

The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progressionSemantic proximity Read

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosisSemantic proximity Read

A multi-pronged human microglia response to Alzheimer’s disease Aβ pathologySemantic proximity Read

A reproducible human brain tissue model to study physiological and disease-associated microglia phenotypesSemantic proximity Read

All roads lead to heterogeneity: The complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer’s diseaseSemantic proximity Read