Article
Itch/AIP4 associates with and promotes p63 protein degradation.
Cell cycle (Georgetown, Tex.) - 1 Aug 2006
Rossi Mariangela, De Simone Marco, Pollice Alessandra, Santoro Raffaela, La Mantia Girolama, Guerrini Luisa, Calabrò Viola
Abstract excerpt
p63, a protein related to the tumor suppressor p53, is a transcription factor that plays an important role in epidermal differentiation and limb development. The gene has two distinct promoters that allow the formation of proteins that either contain (TA) or lack (DeltaN) a transactivation domain. In addition, alternative splicing at the 3' end generates proteins with different C-termini, denoted alpha, beta and...
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