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Article

Master regulatory role of p63 in epidermal development and disease.

Cellular and molecular life sciences : CMLS - 1 Apr 2018

Soares Eduardo, Zhou Huiqing

Abstract excerpt

The transcription factor p63 is a master regulator of epidermal development. Mutations in p63 give rise to human developmental diseases that often manifest epidermal defects. In this review, we summarize major p63 isoforms identified so far and p63 mutation-associated human diseases that show epidermal defects. We discuss key roles of p63 in epidermal keratinocyte proliferation and differentiation, emphasizing...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29103147
DOI: 10.1007/s00018-017-2701-z
PMCID: PMC5843667

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