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Article

FGF8, c-Abl and p300 participate in a pathway that controls stability and function of the ΔNp63α protein.

Human molecular genetics - 1 Aug 2015

Restelli Michela, Molinari Elisa, Marinari Barbara, Conte Daniele, Gnesutta Nerina, Costanzo Antonio, Merlo Giorgio Roberto, Guerrini Luisa

Abstract excerpt

The p63 transcription factor, homolog to the p53 tumor suppressor gene, plays a crucial role in epidermal and limb development, as its mutations are associated to human congenital syndromes characterized by skin, craniofacial and limb defects. While limb and skin-specific p63 transcriptional targ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Limb Deformities, Congenital

Share to p300-CBP Transcription Factors

Share to Proto-Oncogene Proteins c-abl

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Source

Open in PubMed Open full text

Identifiers

PMID: 25911675
DOI: 10.1093/hmg/ddv151
PMCID: PMC4492388

Genes

FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25911675-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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FGF8, c-Abl and p300 participate in a pathway that controls stability and function of the ΔNp63α protein.PMID 25911675Read ↗

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p63: A Master Regulator at the Crossroads Between Development, Senescence, Aging, and CancerSemantic proximity Read ↗

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