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Article

Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant.

Cell cycle (Georgetown, Tex.) - 15 Sept 2010

Bellomaria A, Barbato Gaetano, Melino G, Paci M, Melino Sonia

Abstract excerpt

The E3 ubiquitin ligase Itch mediates the degradation of the p63 protein. Itch contains four WW domains which are pivotal for the substrate recognition process. Indeed, this domain is implicated in several signalling complexes crucially involved in human diseases including Muscular Dystrophy, Alz...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20855944

Genes

ITCH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20855944-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant.PMID 20855944Read ↗

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