Article
Recessive genetic mechanisms in the oncogenesis of prostatic carcinoma.
Scandinavian journal of urology and nephrology. Supplementum - 1 Jan 1991
Bergerheim U S, Collins V P, Ekman P, Kunimi K
Abstract excerpt
A detailed deletion mapping of a series of human prostatic carcinomas, using restriction fragment length polymorphism (RFLP) analysis of all chromosomes, showed allelic losses on individual chromosomes at variable frequencies. Allelic losses occurred on chromosomal arms 8p, 10pq, 16q and 18q in more than 30% of the cases. Losses of genetic information from one or two of the chromosomes 8, 10, or 16 were always...
Topics
- Alleles
- Blotting, Southern
- Chromosome Deletion
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 16
- Chromosomes, Human, Pair 8
- DNA, Neoplasm
- Humans
- Male
- Polymorphism, Restriction Fragment Length
- Prostatic Neoplasms