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Article

Tumour-suppressor genes in prostatic oncogenesis: a positional approach.

British journal of urology - 1 Mar 1997

Bookstein R, Bova G S, MacGrogan D, Levy A, Isaacs W B

Abstract excerpt

Genetic alterations, such as mutation, methylation and aneuploidy, are thought to underlie the multistep genesis and progression of many human cancers. However, the genetic events occurring in prostatic oncogenesis are still relatively poorly understood. This is especially so in early-stage tumours, in which mutations of known oncogenes or tumour-suppressor genes appear to be quite infrequent. Allelic losses of...

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Identifiers

PMID: 9088270
DOI: 10.1111/j.1464-410x.1997.tb00798.x

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