Article
Recessive oncogenes.
Cancer - 1 Feb 1993
Bookstein R, Allred D C
Abstract excerpt
Tumor-suppressor genes (antioncogenes or recessive oncogenes) are cancer genes that achieve their oncogenic effect by mutational inactivation of both normal alleles. By contrast, oncogenes are created from protooncogenes by mutations that lead to aberrant functional activation. Mutation of multip...
Topics
- Alleles
- Disease Susceptibility
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Genes, Retinoblastoma
- Genes, Tumor Suppressor
- Genes, p53
- Genetic Therapy
- Humans
- Male
- Mutation
- Oncogenes
- Prognosis
- Prostatic Neoplasms