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Article

Tumor suppressor genes in prostatic oncogenesis.

Journal of cellular biochemistry. Supplement - 1 Jan 1994

Bookstein R

Abstract excerpt

Mutations of tumor suppressor genes are critical genetic alterations occurring during the genesis and progression of human cancer, and consequently are candidates for use as surrogate endpoint biomarkers. The two most intensively studied suppressor genes, retinoblastoma (Rb) and p53, are mutated in approximately 20-50% of advanced-stage prostate cancers, but only rarely in early tumors. The precise DNA base...

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PMID: 7823594

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