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Article

Aurora-A amplification associated with BRCA2 mutation in breast tumours.

Cancer letters - 8 Apr 2007

Bodvarsdottir Sigridur K, Hilmarsdottir Holmfridur, Birgisdottir Valgerdur, Steinarsdottir Margret, Jonasson Jon G, Eyfjord Jorunn E

Abstract excerpt

Potential interaction of Aurora-A amplification and BRCA2 mutation was examined in breast tumours from BRCA2 999del5 mutation carriers (n=20) and non-carriers (n=41). Aurora-A amplification studied by FISH was significantly more common in breast tumours from BRCA2 mutation carriers (p=0.0005). Extensive Aurora-A amplification was also detected on metaphase chromosomes in three breast epithelial cell lines with...

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Share to Aurora Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Share to Protein Serine-Threonine Kinases

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Source

Identifiers

PMID: 16860930
DOI: 10.1016/j.canlet.2006.06.003

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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