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Article

Gene Amplification and Overexpression of Aurora-C in Breast and Prostate Cancer Cell Lines

1 May 2012

Abstract excerpt

Human aurora kinases are three highly conserved serine/threonine kinases with regulatory function in chromosome alignment, chromosome segregation, and cytokinesis during cell cycle progression and their overexpression associates with malignant transformation and proliferation of cancer cells. Aurora genes are located at loci that are commonly altered in cancers. Aurora-A has oncogenic activity while Aurora-B does...

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PMID: 23581231
DOI: 10.3727/096504013x13589503482978

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