Article
Co-amplification of erbB2, topoisomerase II alpha and retinoic acid receptor alpha genes in breast cancer and allelic loss at topoisomerase I on chromosome 20.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1993
Keith W N, Douglas F, Wishart G C, McCallum H M, George W D, Kaye S B, Brown R
Abstract excerpt
The DNA topoisomerase enzymes are targets for the cytotoxic effects of a number of anticancer agents termed topoisomerase inhibitors. We have analysed breast cancer biopsy specimens for genetic alterations at and around topoisomerase loci in order to obtain molecular insight into factors which ma...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- DNA Topoisomerases, Type II
- DNA, Neoplasm
- ErbB Receptors
- Female
- Gene Amplification
- Humans
- Middle Aged
- Proto-Oncogene Proteins
- Receptor, ErbB-2
- Receptors, Retinoic Acid
- Tretinoin