Article
Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis.
Oncogene - 3 Feb 2005
Tatsuka Masaaki, Sato Sunao, Kitajima Shojiro, Suto Shiho, Kawai Hidehiko, Miyauchi Mutsumi, Ogawa Ikuko, Maeda Masayo, Ota Takahide, Takata Takashi
Abstract excerpt
Aurora kinases are known to play a key role in maintaining mitotic fidelity, and overexpression of aurora kinases has been noted in various tumors. Overexpression of aurora kinase activity is thought to promote cancer development through a loss of centrosome or chromosome number integrity. Here we observed augmentation of G12V-mutated HRAS-induced neoplastic transformation in BALB/c 3T3 A31-1-1 cells transfected...
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