Article
Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.
Immunity - 1 Jul 2006
Broussard Christine, Fleischacker Christine, Fleischecker Christine, Horai Reiko, Chetana Madeva, Venegas Ana M, Sharp Leslie L, Hedrick Stephen M, Fowlkes B J, Schwartzberg Pamela L
Abstract excerpt
Mutations affecting the Tec kinases Itk and Rlk decrease T cell receptor-induced Ca(2+) mobilization and Erk kinase activation and impair both positive and negative thymic selection. Itk(-/-) and Rlk(-/-)Itk(-/-) mice also have decreased CD4:8 T cell ratios, suggestive of altered CD4:8 lineage commitment. Nonetheless, we find that CD8 single-positive (SP) thymocytes and peripheral CD8(+) T cells in these mice do...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.