Article
Impaired T-cell development in the absence of Vav1 and Itk.
European journal of immunology - 1 Dec 2008
Raberger Julia, Boucheron Nicole, Sakaguchi Shinya, Penninger Josef M, Ellmeier Wilfried
Abstract excerpt
Vav1 and the Tec family kinase Itk act in similar T-cell activation pathways. Both molecules interact with members of the Cbl family of E3 ubiquitin ligases, and signaling defects in Vav1(-/-) T cells are rescued upon deletion of Cbl-b. In this study we investigate the relation between Itk and Cbl-b or Vav1 by generating Itk/Cbl-b and Itk/Vav1 double-deficient mice. Deletion of Cbl-b in Itk(-/-) CD4(+) T cells...
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