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Article

Impaired T-cell development in the absence of Vav1 and Itk.

European journal of immunology - 1 Dec 2008

Raberger Julia, Boucheron Nicole, Sakaguchi Shinya, Penninger Josef M, Ellmeier Wilfried

Abstract excerpt

Vav1 and the Tec family kinase Itk act in similar T-cell activation pathways. Both molecules interact with members of the Cbl family of E3 ubiquitin ligases, and signaling defects in Vav1(-/-) T cells are rescued upon deletion of Cbl-b. In this study we investigate the relation between Itk and Cb...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19009524
DOI: 10.1002/eji.200838388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19009524-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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