Article
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Science (New York, N.Y.) - 23 Apr 1999
Schaeffer E M, Debnath J, Yap G, McVicar D, Liao X C, Littman D R, Sher A, Varmus H E, Lenardo M J, Schwartzberg P L
Abstract excerpt
T cell receptor (TCR) signaling requires activation of Zap-70 and Src family tyrosine kinases, but requirements for other tyrosine kinases are less clear. Combined deletion in mice of two Tec kinases, Rlk and Itk, caused marked defects in TCR responses including proliferation, cytokine production, and apoptosis in vitro and adaptive immune responses to Toxoplasma gondii in vivo. Molecular events immediately...
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