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Article

Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk.

Biochemical Society transactions - 1 Nov 2001

Czar M J, Debnath J, Schaeffer E M, Lewis C M, Schwartzberg P L

Abstract excerpt

The Tec kinases have been implicated as important components of signalling pathways downstream of lymphocyte antigen receptors. Activation of these kinases requires two steps: (i) phosphorylation by Src family kinases and (ii) plasma membrane localization, which is mediated by interaction between the pleckstrin homology (PH) domains of Tec kinases and the products of phosphoinositide-3 kinase (PI-3K). Itk and...

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Identifiers

PMID: 11709089
DOI: 10.1042/0300-5127:0290863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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