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Article

Itk is not essential for CD28 signaling in naive T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2005

Li Cheng-Rui, Berg Leslie J

Abstract excerpt

Itk, a member of the Tec family of tyrosine kinases, is critical for TCR signaling, leading to the activation of phospholipase C gamma1. Early biochemical studies performed in tumor cell lines also implicated Itk in CD28 signaling. These data were complemented by functional studies on primary Itk-/- T cells that suggested a negative role for Itk in CD28 signaling. In this report, we describe a thorough analysis...

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Share to CD28 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15814667
DOI: 10.4049/jimmunol.174.8.4475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Itk is not essential for CD28 signaling in naive T cells.PMID 15814667Read ↗

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CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the IntestineSemantic proximity Read ↗

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